As a solo performer, Donehew Pérez has appeared with the Berkeley Symphony, Sacramento Philharmonic, San Francisco Chamber Orchestra, Oakland East Bay Symphony, St. Paul Chamber Orchestra, Cincinnati Symphony, Puerto Rico Symphony Orchestra, Bogotá Philharmonic Orchestra, Sphinx Symphony Orchestra, Sphinx Chamber Orchestra and New World Symphony, among others. As a chamber musician, she has performed with ensembles including Orpheus Chamber Orchestra and East Coast Chamber Orchestra (ECCO), and collaborated with such artists as Joshua Bell, Zuill Bailey, Awadagin Pratt, Anthony McGill, Stewart Goodyear, Fredericka Von Stade, Garry Karr, and members of the Guarneri, Juilliard, and Takács quartets. She has also served as guest concertmaster at the Tucson Symphony and spent two years as a fellow at the New World Symphony, where she was often concertmaster or principal second violin.

An avid teacher and mentor, Donehew Pérez has hosted collegiate-level residencies or masterclasses at Cornell University, the San Francisco Conservatory of Music, Rice University, Dartmouth College, the University of South Africa and Conservatorio de Música de Puerto Rico, to name just a few. In addition, she has led or taken part in residencies through the Kennedy Center, New York Philharmonic, Virginia Arts Festival, Interlochen Arts Center, and a U.S. State Department outreach tour that brought her to Colombia. She has taken part in festivals including Chamber Music Northwest, Mainly Mozart, Aspen Music Festival, Vail International Dance Festival, Encore Chamber Music, and Music in the Vineyards.

She recently recorded the solo violin music for Mosaic, a new method anthology published by the University of Tennessee, Knoxville. Developed to build representation for communities traditionally neglected in classical music, the series highlights works and performances by Black, Latino, Asian, Indigenous and women artists.